The USPSTF makes recommendations about the effectiveness of specific preventive care services for patients without obvious related signs or symptoms. It bases its recommendations on the evidence of both the benefits and harms of the service and an assessment of the balance.

This recommendation applies to adults aged 40 to 59 years with a 10 percent or greater 10-year CVD risk (i.e., risk of having a heart attack or stroke),  without increased bleeding risk (for example, history of GI ulcers, bleeding disorder, or use of medications that increase bleeding risk), and who are willing to take low-dose aspirin daily.

This evidence-based source serves as the foundation for the CDS Connect Aspirin Use to Prevent Cardiovascular Disease: Preventive Medication  artifact.